Take the Manhattan Bridge from Brooklyn. Make a slight left onto Canal Street, turn right onto West Street, and continue onto 11th Avenue. Turn right onto E 14th St, and turn left onto Washington St. Proceed south and turn right onto Bethune Street.
OR: Take the Williamsburg Bridge from Brooklyn onto Delancey Street. Proceed down Delancey Street and turn right onto Chrystie Street, turn left onto E Houston Street, turn right onto Hudson Street. Turn left onto W 11th Street, turn right Greenwich Street and proceed to Bethune Street.
OR: Take the Brooklyn Bridge into Manhattan. Take the Park Row S exit on the left. Keep right to continue on Barclay Street, turn right onto West Street. Continue onto 11th Avenue. Make a right onto W 14th Street. Turn right onto Washington Street and proceed south to turn right onto Bethune Street.